GENOSYS Skin Reboot PDRN Mask Pack 30 Masks UK – Guide
PDRN — also widely known as Polynucleotides — has become one of the most talked-about ingredients in skincare and aesthetics, celebrated for its ability to support skin regeneration at a cellular level. The GENOSYS Skin Reboot PDRN Mask Pack brings this clinically recognised active into a convenient at-home sheet mask format, combining PDRN with a triple barrier complex of Ceramide NP, Panthenol and Allantoin, plus Hydrolyzed Collagen and Elastin for a comprehensive regeneration, barrier repair and anti-ageing treatment in one step. Available as 30 masks in a tissue-style resealable container for convenient one-by-one dispensing.
At Autumn Harmony, this mask is recommended for clients wanting professional-level regenerative skincare at home, backed by nearly 15 years of professional experience and trusted by clients across Surrey, London and beyond.
What Are Polynucleotides (PDRN)?
PDRN (Polydeoxyribonucleotide) — also widely known as Polynucleotides — is derived from highly purified salmon DNA (Oncorhynchus mykiss), which shares a high degree of compatibility with human DNA, making it exceptionally well-tolerated by the skin. It acts as a cellular signal that encourages the skin’s natural repair mechanisms — including collagen synthesis, microcirculation and tissue regeneration.
Polynucleotides have gained significant attention across social media and in aesthetics clinics, where they are used in injectable PN treatments for skin regeneration. The GENOSYS Skin Reboot PDRN Mask delivers the same active science in a topical sheet mask format — listed on the INCI as Sodium DNA.
How the Mask Works: Three Steps
- Step 1 — Cooling & Calming: A gentle cooling mechanism powered by Xylitol — without menthol or alcohol — delivers rapid calming effects. The ultra-thin sheet adheres seamlessly to every contour of the face for immediate comfort and soothing.
- Step 2 — Barrier Strengthening: A triple barrier complex of high-content Panthenol, Ceramide NP and Allantoin provides targeted care to repair and strengthen weakened skin — not simple hydration, but active barrier restoration.
- Step 3 — Anti-Ageing: PDRN extracted from salmon DNA, Hydrolyzed Collagen and Hydrolyzed Elastin deliver advanced anti-ageing care, supporting cellular regeneration, collagen synthesis and improved skin elasticity.
Key Ingredients & What They Do
PDRN — Sodium DNA (Polynucleotides)
Purified salmon DNA fragments that act as a cellular signal to encourage the skin’s natural repair mechanisms — collagen synthesis, microcirculation and tissue regeneration. Helps skin recover from environmental stress and improves elasticity and resilience over time.
Triple Barrier Complex
- Ceramide NP: A skin-identical lipid that restores and reinforces the skin’s natural barrier, reducing moisture loss and improving resilience
- Panthenol (Pro-Vitamin B5): Deeply hydrating and soothing, helping to maintain moisture levels and support skin comfort
- Allantoin: Calms and conditions the skin, reducing sensitivity and supporting a smoother, more comfortable texture
Hydrolyzed Collagen & Hydrolyzed Elastin
Help improve skin suppleness and support a firmer, more youthful-looking complexion with regular use.
Niacinamide
Strengthens the skin barrier, supports an even skin tone and helps reduce redness and inflammation.
Xylitol (Cooling Agent)
A gentle, alcohol-free and menthol-free cooling agent that delivers a rapid calming and refreshing effect on application — suitable even for sensitive or reactive skin.
Who This Mask Is For
- Skin needing deep hydration and barrier repair
- Post-treatment skin recovering from microneedling, peels or skin boosters
- Sensitive, reactive or inflamed skin requiring gentle regenerative care
- Anyone wanting to improve elasticity and reduce signs of fatigue or dullness
- Those interested in Polynucleotide skincare as a complement to injectable PN treatments
- Anyone looking for a professional-grade weekly skin reboot at home
How to Use
- After cleansing and toning, unfold the GENOSYS Skin Reboot PDRN Mask and apply to the face
- Leave on for 15–20 minutes — you will feel the gentle xylitol cooling effect as the mask works
- Remove and gently pat any remaining essence into the skin
- Follow with moisturiser to seal in the benefits
Use 1–2 times per week, or as directed following a professional treatment.
Where It Fits in Your GENOSYS Routine
- Weekly treatment: Snow O2 Cleanser → Snow Booster Toner → Skin Reboot PDRN Mask (15–20 mins) → Moisturiser
- Post-treatment: Use as directed by your Skin Specialist following microneedling, peels or skin boosters
Used in Our Clinic
At Autumn Harmony, regenerative masks are a core part of our post-treatment homecare recommendations. Products are selected based on real client use and results within a clinical environment.
Frequently Asked Questions
What are Polynucleotides (PDRN) and why are they trending?
Polynucleotides (PDRN) are purified DNA fragments derived from salmon DNA that support the skin’s natural repair mechanisms. They have become one of the most talked-about ingredients in skincare and aesthetics — the same active science behind popular injectable PN treatments, now available in topical formats like this sheet mask.
Is PDRN the same as Polynucleotides?
Yes — PDRN (Polydeoxyribonucleotide) and Polynucleotides refer to the same class of ingredient. On the INCI ingredient list it appears as Sodium DNA.
Why is PDRN derived from salmon DNA?
Salmon DNA shares a high degree of compatibility with human DNA, making it exceptionally well-tolerated by the skin. It is highly purified before use in skincare formulations.
How does the xylitol cooling work without menthol?
Xylitol creates a gentle cooling sensation through an endothermic reaction — without the potential irritation of menthol or alcohol, making it suitable for sensitive and reactive skin types.
How often should I use the PDRN Mask?
1–2 times per week as a regular treatment, or as directed following a professional facial or skin treatment.
Can I use this mask alongside injectable Polynucleotide treatments?
Yes — topical PDRN masks can complement injectable PN treatments as part of an ongoing homecare routine. Always follow the advice of your aesthetic practitioner regarding timing after injectable treatments.
Is the 30-mask pack good value?
At 30 masks per pack, it provides 15–30 weeks of regular use at 1–2 masks per week — excellent value for a consistent regenerative treatment at home.
Why Choose Autumn Harmony
- Nearly 15 years of professional beauty experience
- Products selected and used within real client treatments
- Trusted by clients across Surrey, London and beyond
- Carefully curated professional-grade skincare
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